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Article

Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.

Molecular cancer - 23 Jun 2013

Chen I-Chieh, Chiang Wei-Fan, Liu Shyun-Yeu, Chen Pei-Fen, Chiang Hung-Che

Abstract excerpt

BACKGROUND: Sirtuins (SIRT1-7) are a family of NAD-dependent deacetylases, which play an important role in regulating cancer tumorigenesis; however, their role in oral cancer has been controversial. SIRT3 is localized in the mitochondria, where it deacetylates and activates several enzymes involved in cellular redox balance and defense against oxidative damage. RESULTS: We found that compared with normal human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23800187
DOI: 10.1186/1476-4598-12-68
PMCID: PMC3694519

Genes

SIRT3
SIRT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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