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Article

HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment

15 Dec 2021

Abstract excerpt

Rationale: Tumor-associated macrophages (TAMs), generally displaying the pro-tumor M2-like phenotype, strongly influence the progression of colorectal cancer (CRC) via their immunosuppressive activities. The high-mobility gene group A2 (HMGA2), an oncoprotein, is aberrantly overexpressed in CRC cells. However, the mechanisms by which tumor-derived HMGA2 modulates tumor microenvironment in CRC remain poorly...

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PMID: 34976223
DOI: 10.7150/thno.65411

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