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Article

LAMA1 Promotes Tumor-Associated Macrophages Polarization Towards the M2 Phenotype and Induces Colorectal Cancer.

Applied biochemistry and biotechnology - 1 Feb 2026

Lu Ji-Ying, Jin Xi-Han, Jin Zhe-Kang, Yang Meng-Xiang, Wu Jing

Abstract excerpt

Tumor-associated macrophages (TAMs) differentiate into two main types based on signals from their microenvironment: the classically activated M1 type and the alternatively activated M2 type. An increased presence of M2-type TAMs has been identified in colorectal cancer patients, and the laminin alpha-1 chain (LAMA1), a key structural component of the extracellular matrix, plays a pivotal role in tumor metastasis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41484729
DOI: 10.1007/s12010-025-05555-z

Genes

LAMA1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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