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Article

CD8+ T cells inhibit metastasis and CXCL4 regulates its function

1 Apr 2021

Abstract excerpt

Abstract Background The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of immune cells in metastasis will guide the development of treatments improving patient survival. Methods We used syngeneic orthotopic mouse tumour models (wild-type, NOD/scid and Nude), employed knockout ( CD8 and CD4 ) models and administered CXCL4. Tumours and lungs were analysed for cancer cells by...

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PMID: 33795809
DOI: 10.1038/s41416-021-01338-5

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