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Article

Protecting the Aging Genome.

Trends in cell biology - 1 Feb 2020

Petr Michael A, Tulika Tulika, Carmona-Marin Lina M, Scheibye-Knudsen Morten

Abstract excerpt

Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of these pathways can lead to accelerated or premature aging and age-related decline in vital organs,...

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PMID: 31917080
DOI: 10.1016/j.tcb.2019.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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