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ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

23 Sept 2021

Abstract excerpt

ISG15 is an ubiquitin-like modifier that is associated with reduced survival rates in breast cancer patients. The mechanism by which ISG15 achieves this however remains elusive. We demonstrate that modification of Rab GDP-Dissociation Inhibitor Beta (GDI2) by ISG15 (ISGylation) alters endocytic recycling of the EGF receptor (EGFR) in non-interferon stimulated cells using CRISPR-knock out models for ISGylation. By...

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PMID: 34556814
DOI: 10.1038/s41388-021-02017-8

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