Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing

23 Jan 2020

Abstract excerpt

Abstract Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the ISG UBA7 is a tumor suppressor in breast cancer. UBA7 encodes an enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immunotherapy and Immune Responses
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31974171
DOI: 10.1158/2159-8290.cd-19-0608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor KillingPMID 31974171Read ↗

The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15Semantic proximity Read ↗

The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancerSemantic proximity Read ↗

ISG15 and ISGylation in Human DiseasesSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune ResponseSemantic proximity Read ↗

ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive systemSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read ↗

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cellsSemantic proximity Read ↗

ISG15: A link between innate immune signaling, DNA replication, and genome stabilitySemantic proximity Read ↗

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.