Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISGylation governs the oncogenic function of Ki-Ras in breast cancer.

Oncogene - 6 Feb 2014

Burks J, Reed R E, Desai S D

Abstract excerpt

Aberrant expression of the oncogenic Kirsten-Ras (Ki-Ras) and interferon-stimulated gene 15 (ISG15) pathways is common in breast and other cancers. However, whether these dysregulated pathways cooperate to promote malignancy is not known. This study links Ki-Ras and ISG15 in a previously unidentified regulatory loop that may underlie malignant transformation of mammary cells. We show that oncogenic Ki-Ras...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ubiquitins
Share to Autophagy
Share to Cell Growth Processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Cytokines

Share to Genes, ras

Share to NIH 3T3 Cells

Share to ras Proteins

Source

Identifiers

PMID: 23318454
DOI: 10.1038/onc.2012.633

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISGylation governs the oncogenic function of Ki-Ras in breast cancer.PMID 23318454Read ↗

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signallingSemantic proximity Read ↗

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cellsSemantic proximity Read ↗

ISG15: A link between innate immune signaling, DNA replication, and genome stabilitySemantic proximity Read ↗

ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive systemSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15Semantic proximity Read ↗

ISG15 and ISGylation in Human DiseasesSemantic proximity Read ↗

Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15Semantic proximity Read ↗

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor KillingSemantic proximity Read ↗

The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancerSemantic proximity Read ↗

ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma.Semantic proximity Read ↗

ISG15: A double edged sword in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.