Article

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

2023-03-16

Abstract excerpt

DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that IFN promotes replication fork stability, cell proliferation and survival in BRCA1/2-defective cancer cells and rescues the lethality of BRCA2-deficient mouse embryonic stem cell...

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Literature Corpus work: 5e02017b-6f1a-56bd-aac7-1b27d283870b
DOI: 10.1101/2023.03.16.533020

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