LTA4H rs2660845 association with montelukast response in early and late-onset asthma.

doi:10.1371/journal.pone.0257396

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Article

LTA4H rs2660845 association with montelukast response in early and late-onset asthma.

PloS one - 1 Jan 2021

Maroteau Cyrielle, Espuela-Ortiz Antonio, Herrera-Luis Esther, Srinivasan Sundararajan, Carr Fiona, Tavendale Roger, Wilson Karen, Hernandez-Pacheco Natalia, Chalmers James D, Turner Steve, Mukhopadhyay Somnath, Maitland-van der Zee Anke-Hilse, Burchard Esteban G, Pino-Yanes Maria, Young Simon, Lassi Glenda, Platt Adam, Palmer Colin N A

Abstract excerpt

Leukotrienes play a central pathophysiological role in both paediatric and adult asthma. However, 35% to 78% of asthmatics do not respond to leukotriene inhibitors. In this study we tested the role of the LTA4H regulatory variant rs2660845 and age of asthma onset in response to montelukast in ethnically diverse populations. We identified and genotyped 3,594 asthma patients treated with montelukast (2,514...

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PMID: 34550981
DOI: 10.1371/journal.pone.0257396
PMCID: PMC8457475

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