Identification of a new locus at 16q12 associated with time to asthma onset.

doi:10.1016/j.jaci.2016.03.018

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Article

Identification of a new locus at 16q12 associated with time to asthma onset.

The Journal of allergy and clinical immunology - 1 Oct 2016

Sarnowski Chloé, Sugier Pierre-Emmanuel, Granell Raquel, Jarvis Debbie, Dizier Marie-Hélène, Ege Markus, Imboden Medea, Laprise Catherine, Khusnutdinova Elza K, Freidin Maxim B, Cookson William O C, Moffatt Miriam, Lathrop Mark, Siroux Valérie, Ogorodova Ludmila M, Karunas Alexandra S, James Alan, Probst-Hensch Nicole M, von Mutius Erika, Pin Isabelle, Kogevinas Manolis, Henderson A John, Demenais Florence, Bouzigon Emmanuelle

Abstract excerpt

BACKGROUND: Asthma is a heterogeneous disease in which age of onset plays an important role. OBJECTIVE: We sought to identify the genetic variants associated with time to asthma onset (TAO). METHODS: We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry)...

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Identifiers

PMID: 27130862
DOI: 10.1016/j.jaci.2016.03.018

Genes

CYLD
GSDMA
ZPBP2
NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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