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Article

The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.

BMC medical genetics - 29 Dec 2011

Tulah Asif S, Parker Stuart G, Moffatt Miriam F, Wardlaw Andrew J, Connolly Martin J, Sayers Ian

Abstract excerpt

BACKGROUND: We have previously shown evidence that polymorphisms within genes controlling leukotriene B4 (LTB4) production (ALOX5AP and LTA4H) are associated with asthma susceptibility in children. Evidence also suggests a potential role of LTB4 in COPD disease mechanisms including recruitment of neutrophils to the lung. The aim of the current study was to see if these SNPs and those spanning the receptor genes...

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Identifiers

PMID: 22206291
DOI: 10.1186/1471-2350-12-173
PMCID: PMC3267686

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