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Clinical and genetic factors are associated with kidney complications in African children with sickle cell anaemia.

British journal of haematology - 1 Jan 2022

Adebayo Oyindamola Christiana, Betukumesu DieuMerci Kabasele, Nkoy Agathe Bikupe, Adesoji Oluyomi Modupe, Ekulu Pepe Mfutu, Van den Heuvel Lambertus P, Levtchenko Elena N, Labarque Veerle

Abstract excerpt

Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in the paediatric population. In this cross-sectional study, we enrolled 361 sickle cell disease children from the Democratic Republic of Congo. Participants were genotyped for the beta (β)-globin gene, apolipoprotein L1 (APOL1) risk variants, and haem oxygenase-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34545573
DOI: 10.1111/bjh.17832

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