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Article

Identifying causal variants by fine mapping across multiple studies.

PLoS genetics - 1 Sept 2021

LaPierre Nathan, Taraszka Kodi, Huang Helen, He Rosemary, Hormozdiari Farhad, Eskin Eleazar

Abstract excerpt

Increasingly large Genome-Wide Association Studies (GWAS) have yielded numerous variants associated with many complex traits, motivating the development of "fine mapping" methods to identify which of the associated variants are causal. Additionally, GWAS of the same trait for different populations are increasingly available, raising the possibility of refining fine mapping results further by leveraging different...

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PMID: 34543273
DOI: 10.1371/journal.pgen.1009733
PMCID: PMC8491908

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