Leveraging genetic variability across populations for the identification of causal variants.

Abstract excerpt

Genome-wide association studies have been performed extensively in the last few years, resulting in many new discoveries of genomic regions that are associated with complex traits. It is often the case that a SNP found to be associated with the condition is not the causal SNP, but a proxy to it as a result of linkage disequilibrium. For the identification of the actual causal SNP, fine-mapping follow-up is...

Topics

• Breast Neoplasms
• Chromosome Mapping
• Genetic Linkage
• Genetic Variation
• Genetics, Population
• Genome-Wide Association Study