Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactive matrix Gla protein is causally related to adverse health outcomes: a Mendelian randomization study in a Flemish population.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2015

Liu Yan-Ping, Gu Yu-Mei, Thijs Lutgarde, Knapen Marjo H J, Salvi Erika, Citterio Lorena, Petit Thibault, Carpini Simona Delli, Zhang Zhenyu, Jacobs Lotte, Jin Yu, Barlassina Cristina, Manunta Paolo, Kuznetsova Tatiana, Verhamme Peter, Struijker-Boudier Harry A, Cusi Daniele, Vermeer Cees, Staessen Jan A

Abstract excerpt

Matrix Gla-protein is a vitamin K-dependent protein that strongly inhibits arterial calcification. Vitamin K deficiency leads to production of inactive nonphosphorylated and uncarboxylated matrix Gla protein (dp-ucMGP). The risk associated with dp-ucMGP in the population is unknown. In a Flemish population study, we measured circulating dp-ucMGP at baseline (1996-2011), genotyped MGP, recorded adverse health...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Belgium
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 12

Share to Environmental Exposure

Share to Extracellular Matrix Proteins

Share to Kaplan-Meier Estimate

Share to Proportional Hazards Models

Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 25421980
DOI: 10.1161/HYPERTENSIONAHA.114.04494

Genes

MGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactive matrix Gla protein is causally related to adverse health outcomes: a Mendelian randomization study in a Flemish population.PMID 25421980Read ↗

The risk of nephrolithiasis is causally related to inactive matrix Gla protein, a marker of vitamin K status: a Mendelian randomization study in a Flemish population.Semantic proximity Read ↗

Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies.Semantic proximity Read ↗

Cardiovascular-kidney-metabolic health, genetic susceptibility, and incident cancer risk: a prospective UK biobank cohort and machine learning study.Semantic proximity Read ↗

GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levelsSemantic proximity Read ↗

Serum calcium and 25-hydroxyvitamin D in relation to longevity, cardiovascular disease and cancer: a Mendelian randomization studySemantic proximity Read ↗

Plasma levels of vitamin K and the risk of ischemic heart disease: a Mendelian randomization study.Semantic proximity Read ↗

Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.Semantic proximity Read ↗

Plasma levels of the anti-coagulation protein C and the risk of ischaemic heart disease. A Mendelian randomisation study.Semantic proximity Read ↗

ACLY and CKD: A Mendelian Randomization AnalysisSemantic proximity Read ↗

Genetically Predicted Lifelong Circulating 25(OH)D Levels are Associated With Serum Calcium Levels and Kidney Stone Risk.Semantic proximity Read ↗

Genetic association between inflammatory factors and abdominal aortic calcification: Insights from a genome-wide association study.Semantic proximity Read ↗

Genetically Higher Level of Mannose Has No Impact on Cardiometabolic Risk Factors: Insight from Mendelian Randomization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.