Article
α-klotho reduces susceptibility to osteoarthritis: evidence from cross-sectional studies and Mendelian randomization.
Frontiers in endocrinology - 1 Jan 2024
Li Zhao, Li Zhong, Cheng Qisheng, Nie Xinlin, Cui Yu, Du Bing, Ren Taotao, Xu Yibo, Ma Teng
Abstract excerpt
Background: Despite extensive research, the association between serum α-klotho levels and osteoarthritis (OA) remains unclear, predominantly relying on findings from OA mouse models. This study used data from the National Health and Nutrition Examination Survey (NHANES) to conduct a cross-sectional study examining the relationship between α-klotho and human OA. In addition, we used Mendelian randomization (MR) to...
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