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Article

A novel integrated approach to predicting cancer immunotherapy efficacy

26 Apr 2023

Abstract excerpt

Immunotherapies have revolutionized cancer treatment modalities; however, predicting clinical response accurately and reliably remains challenging. Neoantigen load is considered as a fundamental genetic determinant of therapeutic response. However, only a few predicted neoantigens are highly immunogenic, with little focus on intratumor heterogeneity (ITH) in the neoantigen landscape and its link with different...

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PMID: 37100920
DOI: 10.1038/s41388-023-02670-1

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