Article
Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2022
Mattu Sandra, Zavattari Patrizia, Kowalik Marta Anna, Serra Marina, Sulas Pia, Pal Rajesh, Puliga Elisabetta, Sutti Salvatore, Foglia Beatrice, Parola Maurizio, Albano Emanuele, Giordano Silvia, Perra Andrea, Columbano Amedeo
Abstract excerpt
BACKGROUND & AIMS: Activation of the kelch-like ECH-associated protein 1 (Keap1)-nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway has been associated with metabolic reprogramming in many tumors, including hepatocellular carcinoma (HCC). However, the contribution of Nrf2 mutations in this process remains elusive. Here, we investigated the occurrence of Nrf2 mutations in distinct models of mouse...
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