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Article

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae.

eLife - 15 Sept 2021

Jiang Pengyao, Ollodart Anja R, Sudhesh Vidha, Herr Alan J, Dunham Maitreya J, Harris Kelley

Abstract excerpt

Although studies of Saccharomyces cerevisiae have provided many insights into mutagenesis and DNA repair, most of this work has focused on a few laboratory strains. Much less is known about the phenotypic effects of natural variation within S. cerevisiae's DNA repair pathways. Here, we use natural polymorphisms to detect historical mutation spectrum differences among several wild and domesticated S. cerevisiae...

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Identifiers

PMID: 34523420
DOI: 10.7554/eLife.68285
PMCID: PMC8497059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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