Article
Rapid reactivation of extralymphoid CD4 T cells during secondary infection.
PloS one - 1 Jan 2011
Chapman Timothy J, Lambert Kris, Topham David J
Abstract excerpt
After infection, extralymphoid tissues are enriched with effector and memory T cells of a highly activated phenotype. The capacity for rapid effector cytokine response from extralymphoid tissue-memory T cells suggests these cells may perform a 'sentinel' function in the tissue. While it has been demonstrated that extralymphoid CD4+ T cells can directly respond to secondary infection, little is known about how...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD4-Positive T-Lymphocytes
- Cell Count
- Cell Proliferation
- Chemokines
- Immunity, Innate
- Inflammation
- Influenza A virus
- Lectins, C-Type