Article

Secondary lymphoid organ endothelial cells prime alloreactive CD4 <sup>+</sup> T cells to trigger acute graft-versus-host disease

2025-10-07

Abstract excerpt

Donor CD4⁺ T cell priming is a pivotal determinant of acute graft-versus-host disease (aGvHD) after allogeneic hematopoietic cell transplantation (allo-HCT). While professional hematopoietic antigen-presenting cells (APCs) have long been implicated in the pathogenesis of aGvHD, the contribution of non-hematopoietic APCs has remained unclear. Here, we show that naïve alloreactive CD4⁺ T cells initially localize and...

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Literature Corpus work: 4ccf7502-ca16-5a10-aa0e-0b850aca32f3
DOI: 10.1101/2025.10.07.677751

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Secondary lymphoid organ endothelial cells prime alloreactive CD4 <sup>+</sup> T cells to trigger acute graft-versus-host diseaseDOI 10.1101/2025.10.07.677751Read

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