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Article

Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes.

Cell reports - 12 Sept 2013

Roybon Laurent, Lamas Nuno J, Garcia Alejandro D, Yang Eun Ju, Sattler Rita, Lewis Vernice J, Kim Yoon A, Kachel C Alan, Rothstein Jeffrey D, Przedborski Serge, Wichterle Hynek, Henderson Christopher E

Abstract excerpt

Differentiation of astrocytes from human stem cells has significant potential for analysis of their role in normal brain function and disease, but existing protocols generate only immature astrocytes. Using early neuralization, we generated spinal cord astrocytes from mouse or human embryonic or induced pluripotent stem cells with high efficiency. Remarkably, short exposure to fibroblast growth factor 1 (FGF1) or...

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Source

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Identifiers

PMID: 23994478
DOI: 10.1016/j.celrep.2013.06.021
PMCID: PMC4229657

Genes

FGF1
FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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