Article

Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke

2022-06-08

Abstract excerpt

<title>Abstract</title> <p>Blood-brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial pathophysiological feature of acute ischemic stroke. Dysregulation of multiple neurovascular unit (NVU) cell types is involved in BBB breakdown in ischemic stroke that may be further aggravated by reperfusion therapy. Therefore, therapeutic co-targeting...

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Literature Corpus work: fa9b5315-b3c9-5e3c-aafb-028331eeab39
DOI: 10.21203/rs.3.rs-1379225/v1

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Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic strokeDOI 10.21203/rs.3.rs-1379225/v1Read

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