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Article

Brain-specific PAPP-A knock-out mice?

Experimental gerontology - 15 Oct 2021

Bale Laurie K, West Sally A, Conover Cheryl A

Abstract excerpt

PAPP-A knock-out (KO) mice are a valuable model for investigating the effects of down-regulating localized insulin-like growth factor (IGF) action, which has been shown to extend lifespan and healthspan when the PAPP-A gene is globally deleted. Based on previous mouse models of brain-specific reduction in IGF signaling associated with longevity, we sought to generate brain-specific PAPP-A KO mice and determine...

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Identifiers

PMID: 34509589
DOI: 10.1016/j.exger.2021.111548
PMCID: PMC8494012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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