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Article

Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice.

GeroScience - 1 Apr 2023

Li Xinna, Hager Mary, McPherson Madaline, Lee Michael, Hagalwadi Riha, Skinner Mary E, Lombard David, Miller Richard A

Abstract excerpt

Deletion of pregnancy-associated plasma protein-A (PAPP-A), a protease that cleaves some but not all IGF1 binding proteins, postpones late-life diseases and extends lifespan in mice, but the mechanism of this effect is unknown. Here we show that PAPP-A knockout (PKO) mice display a set of changes, in multiple tissues, that are characteristic of other varieties of slow-aging mice with alterations in GH production...

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Identifiers

PMID: 36542300
DOI: 10.1007/s11357-022-00692-3
PMCID: PMC9886707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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