Article
Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.
Human molecular genetics - 15 Jun 2013
Sun Ying, Zamzow Matt, Ran Huimin, Zhang Wujuan, Quinn Brian, Barnes Sonya, Witte David P, Setchell Kenneth D R, Williams Michael T, Vorhees Charles V, Grabowski Gregory A
Abstract excerpt
Individual saposin A (A-/-) and saposin B (B-/-)-deficient mice show unique phenotypes caused by insufficient degradation of myelin-related glycosphingolipids (GSLs): galactosylceramide and galactosylsphingosine and sulfatide, respectively. To gain insight into the interrelated functions of saposins A and B, combined saposin AB-deficient mice (AB-/-) were created by knock-in point mutations into the saposins A...
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