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Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex

10 Sept 2021

Abstract excerpt

Insulin resistance is present in one-quarter of the general population, predisposing these people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of insulin resistance in this population using induced pluripotent stem cell-derived (iPSC-derived) myoblasts (iMyos). We found that these cells exhibited a large network of altered protein phosphorylation in vitro. Integrating these...

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PMID: 34506305
DOI: 10.1172/jci151818

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