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Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness

23 Dec 2020

Abstract excerpt

Insulin resistance (IR) precedes the development of type 2 diabetes (T2D) and increases cardiovascular disease risk. Although genome wide association studies (GWAS) have uncovered new loci associated with T2D, their contribution to explain the mechanisms leading to decreased insulin sensitivity has been very limited. Thus, new approaches are necessary to explore the genetic architecture of insulin resistance. To...

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PMID: 33362275
DOI: 10.1371/journal.pcbi.1008491

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