Article
Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications.
Nanoscale - 23 Sept 2021
Sharifiaghdam Maryam, Shaabani Elnaz, Sharifiaghdam Zeynab, De Keersmaecker Herlinde, Lucas Bart, Lammens Joris, Ghanbari Hossein, Teimoori-Toolabi Ladan, Vervaet Chris, De Beer Thomas, Faridi-Majidi Reza, De Smedt Stefaan C, Braeckmans Kevin, Fraire Juan C
Abstract excerpt
Excessive inflammatory responses in wounds are characterized by the presence of high levels of pro-inflammatory M1 macrophages rather than pro-healing M2 macrophages, which leads to delayed wound healing. Macrophage reprogramming from the M1 to M2 phenotype through knockdown of interferon regulatory factor 5 (irf5) has emerged as a possible therapeutic strategy. While downregulation of irf5 could be achieved by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.