Article
Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing.
Biomaterials - 1 Sept 2018
Gauthier Anne, Fisch Andreas, Seuwen Klaus, Baumgarten Birgit, Ruffner Heinz, Aebi Alexandra, Rausch Martin, Kiessling Fabian, Bartneck Matthias, Weiskirchen Ralf, Tacke Frank, Storm Gert, Lammers Twan, Ludwig Marie-Gabrielle
Abstract excerpt
Glucocorticoids are well established anti-inflammatory agents, however, their use to treat chronic inflammatory diseases is limited due to a number of serious side effects. For example, long-term local treatment of chronic wounds with glucocorticoids is prohibited by dysregulation of keratinocyte and fibroblast function, leading to skin thinning. Here, we developed and tested liposome formulations for local...
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