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Article

Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics.

Biomaterials - 1 Jun 2015

Mulens-Arias Vladimir, Rojas José M, Pérez-Yagüe Sonia, Morales María P, Barber Domingo F

Abstract excerpt

Polyethylenimine (PEI) is widely used as transfection agent in preclinical studies, both in vitro and in vivo. Due to their unique chemical and physical properties, SPIONs (superparamagnetic iron oxide nanoparticles) have been thoroughly studied as nanocarriers. PEI appears to activate different...

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PMID: 25818455
DOI: 10.1016/j.biomaterials.2015.02.068

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TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25818455-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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