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Article

Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries.

Biomaterials - 1 May 2026

O'Brien Erin M, Tylek Tina, Geisler Hannah C, Mukalel Alvin J, Whitaker Ricardo C, Sung Samuel, Binder-Markey Benjamin I, Weissman Drew, Mitchell Michael J, Spiller Kara L

Abstract excerpt

The use of macrophage cell therapies is limited by their tendency to change phenotype in response to external cues in situ. Here we demonstrate that an optimized lipid nanoparticle (LNP) formulation effectively delivers IL4 mRNA to human and murine primary macrophages, resulting in rapid transfection, IL-4 secretion, and reparative phenotype modulation. In a model of murine volumetric muscle loss, adoptively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41317703
DOI: 10.1016/j.biomaterials.2025.123869
PMCID: PMC13112448

Genes

IL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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