Article
The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.
Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2021
Vadevoo Sri Murugan Poongkavithai, Gunassekaran Gowri Rangaswamy, Lee ChaeEun, Lee NaHye, Lee Jiyoun, Chae Sehyun, Park Jae-Yong, Koo JaeHyung, Lee Byungheon
Abstract excerpt
Expression and function of odorant receptors (ORs), which account for more than 50% of G protein-coupled receptors, are being increasingly reported in nonolfactory sites. However, ORs that can be targeted by drugs to treat diseases remain poorly identified. Tumor-derived lactate plays a crucial role in multiple signaling pathways leading to generation of tumor-associated macrophages (TAMs). In this study, we...
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