Article

Interactions between neutrophils and macrophages harboring gram-negative bacteria promote obesity-associated breast cancer

2024-08-09

Abstract excerpt

<h4>SUMMARY</h4> Obesity promotes a more aggressive breast cancer phenotype. Through spatial and single-cell-based analysis of hormone receptor-negative breast cancers, we identify a subset of tumor-associated neutrophils (TANs) positive for granzyme B (GZMB) enriched in the tumor microenvironment of obese patients. In breast tumors evolved in obese environments, TANs are in proximity of M2 polarized macrophages...

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Literature Corpus work: 8894d8c6-f848-52cf-8f88-a8eb2578f234
DOI: 10.1101/2024.08.08.607253

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