Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype.

doi:10.1158/2326-6066.CIR-18-0749

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Article

Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype.

Cancer immunology research - 1 Mar 2020

Paolini Léa, Adam Clément, Beauvillain Céline, Preisser Laurence, Blanchard Simon, Pignon Pascale, Seegers Valérie, Chevalier Louise-Marie, Campone Mario, Wernert Romuald, Verrielle Véronique, Raro Pedro, Ifrah Norbert, Lavoué Vincent, Descamps Philippe, Morel Alain, Catros Véronique, Tcherkez Guillaume, Lenaers Guy, Bocca Cinzia, Kouassi Nzoughet Judith, Procaccio Vincent, Delneste Yves, Jeannin Pascale

Abstract excerpt

In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, and angiogenesis. However, the factors conferring inflammatory and protumor properties on human macrophages remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed the impact of lactate on human monocyte...

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PMID: 31924656
DOI: 10.1158/2326-6066.CIR-18-0749

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