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Article

A Mutation in DNA Polymerase α Rescues WEE1KO Sensitivity to HU.

International journal of molecular sciences - 30 Aug 2021

Eekhout Thomas, Pedroza-Garcia José Antonio, Kalhorzadeh Pooneh, De Jaeger Geert, De Veylder Lieven

Abstract excerpt

During DNA replication, the WEE1 kinase is responsible for safeguarding genomic integrity by phosphorylating and thus inhibiting cyclin-dependent kinases (CDKs), which are the driving force of the cell cycle. Consequentially, wee1 mutant plants fail to respond properly to problems arising during DNA replication and are hypersensitive to replication stress. Here, we report the identification of the polα-2 mutant,...

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Identifiers

PMID: 34502313
DOI: 10.3390/ijms22179409
PMCID: PMC8430855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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