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Article

Replication-compromised cells require the mitotic checkpoint to prevent tetraploidization.

Chromosoma - 1 Feb 2011

Zhang Zilai, Arora Sumit, Zhou Yanjiao, Cherry Athena, Wang Teresa S-F

Abstract excerpt

Replication stress often induces chromosome instability. In this study, we explore which factors in replication-compromised cells promote abnormal chromosome ploidy. We expressed mutant forms of either polymerase α (Polα) or polymerase δ (Polδ) in normal human fibroblasts to compromise DNA replic...

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Identifiers

PMID: 20827484
DOI: 10.1007/s00412-010-0292-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20827484-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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