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Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

30 Oct 2012

Abstract excerpt

Human DNA polymerase (pol) λ functions in base excision repair and non-homologous end joining. We have previously shown that DNA pol λ is involved in accurate bypass of the two frequent oxidative lesions, 7,8-dihydro-8-oxoguanine and 1,2-dihydro-2-oxoadenine during the S phase. However, nothing is known so far about the relationship of DNA pol λ with the S phase DNA damage response checkpoint. Here, we show that...

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PMID: 23118481
DOI: 10.1093/nar/gks1016

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