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Article

Arabidopsis thaliana RNase H2 deficiency counteracts the needs for the WEE1 checkpoint kinase but triggers genome instability.

The Plant cell - 1 Sept 2014

Kalhorzadeh Pooneh, Hu Zhubing, Cools Toon, Amiard Simon, Willing Eva-Maria, De Winne Nancy, Gevaert Kris, De Jaeger Geert, Schneeberger Korbinian, White Charles I, De Veylder Lieven

Abstract excerpt

The WEE1 kinase is an essential cell cycle checkpoint regulator in Arabidopsis thaliana plants experiencing replication defects. Whereas under non-stress conditions WEE1-deficient plants develop normally, they fail to adapt to replication inhibitory conditions, resulting in the accumulation of DNA damage and loss of cell division competence. We identified mutant alleles of the genes encoding subunits of the...

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Identifiers

PMID: 25217508
DOI: 10.1105/tpc.114.128108
PMCID: PMC4213155

Genes

WEE1

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