Article
Ocular disease-associated mutations diminish the mitotic chromosome retention ability of PAX6.
Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Jan 2000
Lan Hsin-Chi, Du Ting-Huei, Yao Ya-Li, Yang Wen-Ming
Abstract excerpt
Transcription factors play a key role in maintaining cell identity. One mechanism of such cell memory after multiple rounds of cell division cycles is through persistent mitotic chromosome binding, although how individual transcription factors achieve mitotic chromosome retention is not completely understood. Here we show that PAX6, a lineage-determining transcription factor, coats mitotic chromosomes. Using...
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