Article
Mitotic bookmarking of genes: a novel dimension to epigenetic control.
Nature reviews. Genetics - 1 Aug 2010
Zaidi Sayyed K, Young Daniel W, Montecino Martin A, Lian Jane B, van Wijnen Andre J, Stein Janet L, Stein Gary S
Abstract excerpt
Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation--a mechanism...
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