Article
Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.
Molecular cancer research : MCR - 1 Nov 2018
Zaidi Sayyed K, Nickerson Jeffrey A, Imbalzano Anthony N, Lian Jane B, Stein Janet L, Stein Gary S
Abstract excerpt
Reconfiguration of nuclear structure and function during mitosis presents a significant challenge to resume the next cell cycle in the progeny cells without compromising structural and functional identity of the cells. Equally important is the requirement for cancer cells to retain the transformed phenotype, that is, unrestricted proliferative potential, suppression of cell phenotype, and activation of oncogenic...
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