Article
Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6.
RNA (New York, N.Y.) - 1 Jun 2020
Heskett Michael B, Smith Leslie G, Spellman Paul, Thayer Mathew J
Abstract excerpt
DNA replication occurs on mammalian chromosomes in a cell-type distinctive temporal order known as the replication timing program. We previously found that disruption of the noncanonical lncRNA genes ASAR6 and ASAR15 results in delayed replication timing and delayed mitotic chromosome condensation of human chromosomes 6 and 15, respectively. ASAR6 and ASAR15 display random monoallelic expression and display...
Topics
- Alleles
- Chromosomes, Human, Pair 6
- DNA Replication Timing
- Gene Expression
- Humans
- RNA, Long Noncoding