Article
Screening for colon carcinogens--a new strategy.
Molecular toxicology - 1 Jan 2000
Heddle J A, Kaul H K, Gingerich J D, Couch D B
Abstract excerpt
The major defect of in vivo assays for mutagenic carcinogens may be tissue specificity: a cancer bioassay of a single tissue would not be expected to detect all carcinogens, so the failure of a genetic assay in a single tissue to detect all carcinogens should not be surprising. In the search for an environmental carcinogen responsible for a specific cancer in a particular population, however, it may be that...
Topics
- Animals
- Carcinogens
- Cell Nucleus
- Colonic Neoplasms
- DNA Damage
- In Vitro Techniques
- Mutagenicity Tests
- Mutation
- Sister Chromatid Exchange