Article
Monitoring populations for DNA repair deficiency and for cancer susceptibility.
Environmental health perspectives - 1 May 1996
Au W W, Wilkinson G S, Tyring S K, Legator M S, el Zein R, Hallberg L, Heo M Y
Abstract excerpt
The induction of a mutator phenotype has been hypothesized to cause the accumulation of multiple mutations in the development of cancer. Recent evidence suggests that the mutator phenotype is associated with DNA repair deficiencies. We have been using a challenge assay to study exposed populations to test our hypothesis that exposure to environmental toxicants induce DNA repair deficiency in somatic cells. In...
Topics
- Animals
- Biomarkers
- Carcinogens, Environmental
- Child
- Chromosome Aberrations
- DNA Repair
- Down Syndrome
- Epidermodysplasia Verruciformis
- Female
- Genetic Predisposition to Disease
- Genetic Testing