Article
A report of the U.S. Environmental Protection Agency Gene-Tox Program. Evaluation of mutagenicity assays for purposes of genetic risk assessment.
Mutation research - 1 Jan 2000
Russell L B, Aaron C S, de Serres F, Generoso W M, Kannan K L, Shelby M, Springer J, Voytek P
Abstract excerpt
For the vast majority of chemicals, mammalian germ-line (MG) mutation data do not exist. The question was examined of how best to utilize results of non-MG genotoxicity assays that are included in the Gene-Tox data base to provide information of the likelihood that genetic damage might be induced in and transmitted by the reproductive cells of exposed human beings. Two approaches were used to assess the relative...
Topics
- Animals
- Chromosome Aberrations
- Cricetinae
- Female
- Genes
- Humans
- Male
- Mutagenicity Tests
- Mutagens
- Mutation
- Risk
- Sister Chromatid Exchange