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Article

Genetic method for pre-classification of genotoxins into monofunctional or cross-linking agents.

Environmental and molecular mutagenesis - 1 Jan 1993

Vogel E W, Zijlstra J A, Nivard M J

Abstract excerpt

To characterize environmental carcinogens, there is a need to distinguish monofunctional genotoxic agents from those having cross-linking potential, because chemicals which can cross-link DNA are among the most potent carcinogens in rodents [Barbin and Bartsch, 1989] and humans [Allen et al., 1988; Kaldor et al., 1988]. Here we provide a genetic method for a pre-classification of genotoxins with respect to their...

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PMID: 8491211
DOI: 10.1002/em.2850210403

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