Article
Genetic method for pre-classification of genotoxins into monofunctional or cross-linking agents.
Environmental and molecular mutagenesis - 1 Jan 1993
Vogel E W, Zijlstra J A, Nivard M J
Abstract excerpt
To characterize environmental carcinogens, there is a need to distinguish monofunctional genotoxic agents from those having cross-linking potential, because chemicals which can cross-link DNA are among the most potent carcinogens in rodents [Barbin and Bartsch, 1989] and humans [Allen et al., 198...
Topics
- Alkylating Agents
- Animals
- Chromosome Deletion
- Cross-Linking Reagents
- DNA
- Drosophila
- Female
- Genes, Lethal
- Genes, Recessive
- Intercalating Agents
- Male
- Methylation
- Mutagenesis
- Mutagenicity Tests
- Mutagens
- Mutation
- Reproducibility of Results