Article
Detection of mutations in bacteria and of DNA damage and amplified DNA sequences in mammalian cells as a systematic test strategy for elucidating biological activities of chemical carcinogens.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jan 2000
Pool B L, Eisenbrand G, Preussmann R, Schlehofer J R, Schmezer P, Weber H, Wiessler M
Abstract excerpt
The interdisciplinary evaluation of risks from carcinogens utilizes, inter alia, data on the activities of the compounds in short-term assays. A systematic approach is being used to determine mutagenesis in bacteria (the study of direct activities and specific modes of metabolic activation), DNA damage within primary mammalian cells (DNA single-strand breaks and persistence of damage, by a method extendable to...
Topics
- Animals
- Base Sequence
- Carcinogens
- DNA
- DNA Damage
- Gene Amplification
- Mutagenicity Tests
- Mutation
- Rats
- Rats, Inbred Strains