Article

<i>let-7</i> controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41

2018-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Development of multicellular organisms relies on faithful temporal control of cell fates. In Caenorhabditis elegans , the heterochronic pathway governs temporal patterning of somatic cells. This function may be phylogenetically conserved as several heterochronic genes have mammalian orthologues, and as the heterochronic let-7 miRNA and its regulator LIN28 appear to time the onset of puberty in...

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Literature Corpus work: 418441a1-71c3-5a44-8cd0-096e16ada8c2
DOI: 10.1101/460352

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